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Several other drugs are under investigation in clinical trials or are being considered for clinical trials of prophylaxis or treatment of COVID in the United States and worldwide. Skip directly to site content Skip directly to page options Skip directly to A-Z link. Section Navigation. Minus Related Pages.
Remdesivir Remdesivir is an investigational intravenous drug with broad antiviral activity that inhibits viral replication through premature termination of RNA transcription and has in-vitro activity against SARS-CoV-2 and in-vitro and in-vivo activity against related betacoronaviruses [ ]. The manufacturer is currently transitioning the provision of emergency access to remdesivir from individual compassionate use requests to an expanded access program.
The expanded access program for the United States is under rapid development. Other Drugs Lopinavir-ritonavir did not show promise for treatment of hospitalized COVID patients with pneumonia in a recent clinical trial in China [ 8 ]. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus nCoV in vitro. Cell Res. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
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Broad-spectrum antiviral GS inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med. Int J Antimicrob Agents. Clin Infect Dis. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID associated pneumonia in clinical studies. Biosci Trends. Hydroxychloroquine and azithromycin as a treatment of COVID results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents.
In Press. N Engl J Med. It happens all the time — ask anyone else who does drug research for a living. Better trials are cranking up right now: please, wait for those. Chloroquine and hydroxychloroquine do have pretty significant adverse effects at high doses. Which make sense, since these compounds accumulate in the lysosomes, due to their high logP and basicity. The side effects are modest for most, especially on a 10 days or less regimen.
But in general, chloroquine can be considered safe, at least for standard malaria therapy. I might be a bit more concerned about the combination of chloroquine plus azithromycins for certain patients, as both drugs may lead to QT prolongation. The report I read said dosage is mg once a week, and a fatal dose is only 5 times that. Plus it bioaccumulates, has a long half-life in your body.
Also, it is a bodyweight-sensitive dose, so if you are a small person, take a smaller dose. Thankfully, overdose at the same high level is a very rare occurrence. Great write-up on a dubious therapy. People are gearing up favipiravir too, on similarly preliminary signs.
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But favipiravir is known to be teratogenic and to whack red-cell production. If effective, is there any chance the indiscriminate use to cause the surge of a COVID Chloroquine resistant strain? D, et. It does, however, immediately suggest that a larger and stricter trial be run.
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It was the combination of chloroquine and azithromycin that appeared to be effective. Any thoughts on why that might be? Looking at pubchem, azithromycin does quite a lot of things in quite a lot of systems. These results merit further testing. I would think it would be evident fairly quickly if there was something significant there.
It looks like there were a total of 6 patients in the chloroquine.
Definitely enough to want to do a real study, not enough for the president of the united states to tout from the bully pulpit. People are still looking into a significant role of a secondary bacterial infections in a virus infection. It is therefore very important to include antibacterial drug for lung infections such as azithromycin in the treatment.
Reports earlier were that bacterial pneumonia was oddly not a common sequel of the viral infection in China. The most dreaded complication is staphylococcal pneumonia, which develops days after the initial presentation of viral pneumonia. MRSA is a drug-resistant Staph aureus. We will either win under Trump or lose under Trump. Love it or hate it but it is what it is.
Please clarify. It seems to me that those are indeed the possible outcomes. To be fair, I suppose it could be undecided at the time Trump leaves office. In Poland, chloroquine has been officially approved for use in COVID and our generic drug company Adamed has promised to ramp up production. We knew in that hydroxychloroquine treats lung cells infected with SARS-coronavirus. Was this a case of throwing everything at the wall and hoping something sticks, or is there some history with antimalarials and viruses that made it an interesting test case?
People in here may know better, but chloroquine was known as an antiviral and, I believe, is used as an HIV treatment. I guess it was a drug repurposing strategy using FDA approved drugs that revealed chloroquine and many others. Chloroquine screws up endosomes, and that plasmodium parasite as it cannot stash away excess of iron left after gobbling up all that hemoglobin.
Endosomes also happen to play key role in the virus particles getting into cell — internalizing that receptor-bound virus.
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Biologists who develop transfection vectors, even nonviral one, often use chloroquine to look at the mechanism of the nucleic acid getting inside the cell and being released from the endosomes. The immunosuppressive effects of chloroquine are probably of the same origin. Excellent question.
When you are a biologist interested in a new screen, new biology etc — you often start screening a collection of existing drugs some companies sell plates with all approved drugs. This way any hit will already have lots of data attached to it PK, safety, pharmacology etc. There have been in vitro, in vivo and clinical trials using chlorine for a long time.
I read an article, a few weeks ago, about a doctor, in , who was researching the effect of Chloroquine on the Sars virus.